Attempts to treat epileptic seizures and the disease epilepsy date back to prehistoric times. In every historical epoch, the beliefs which people held about the disease dictated the types of therapy which were used.

In the time before Hippocrates, when the "sacred disease" was thought to be an illness sent by the gods, people would offer sacrifices, seek expiation and take part in religious acts under the instruction of doctor-priest(preferably in the temple) in an attempt to be cured.

The supporters of Hippocratic medicine, who believed that epilepsy had a natural cause, tried to treat the disease using natural means (humoral pathology: the ancient physiological theory of fluids or humors). The treatment was based on dietetics, or a structured, "sensible" lifestyle. This dietetic therapy was based on three pillars: dietary regulations, the regulation of excretions, and physiotherapy.
In addition to dietetics, medicines, which were mainly of a herbal nature, played only a secondary role.

In the Middle Ages, epilepsy was no longer considered to have natural causes but was rather thought to be the work of devils, evil spirits and demons ("morbus daemonicus"). As a result, "therapeutic" methods also changed and took the form of prayer, fasting, offering sacrifices, making pilgrimages or undergoing "exorcisms"

During the Renaissance, chemical substances were increasingly used to treat the "falling sickness". The most important of these were: copper (which had already been used by the Ancient Greeks), zinc oxide, silver nitrate, mercury, bismuth and tin.

Today, there is no doubt that none of these plant or chemical substances had any effect whatsoever on epileptic seizures.

It was not until the second half of the 19th century, when people began to learn more about epilepsy and medicine that drugs were finally found which did have an effect on epileptic seizures. The first two substances which were proven to have an anti-epileptic effect and which are still used today, were bromine (first used in 1857) and phenobarbitone (first used in 1912).

Today, there are about 20 chemical substances which can be used successfully to treat epileptic seizures, either singly or in combination therapy.

Just under 60% of all people with epilepsy can become seizure free under modern drug therapy. In another 20% the seizures can be drastically reduced, and only in one fifth of all epileptic patients do modern anti-epileptic drugs fail to have any effect whatsoever.

Modern epilepsy surgery can help a number of these "therapy-resistant" patients, however.